Lymphocytic Gastritis

Lymphocytic Gastritis (LG) is a type of gastritis caused by some autoimmune factors. Read on to find out all about the definition, causes, symptoms, diagnosis, and treatment options of the disorder.

Lymphocytic Gastritis Definition

It is a rare form of chronic gastritis that is mainly characterized by surface epithelium and lymphocytosis of foveolar. A peculiar benign lymphocyte infiltration into the surface mucosa and various glands can also be seen in the patients. Some case reports show that this condition can be cured by treating the Celiac Disease or Helicobacter infection in the stomach of patients. The disease can occur both in children and adults. According to certain case studies, it can also affect dogs. Lymphocytic Plasmacytic Gastritis is the most common form of Gastritis affecting dogs.

Lymphocytic Gastritis Causes

The exact causes behind this autoimmune disease are yet unknown. Various studies have been done to find out if it is caused by some fungus, bacteria or virus. But all these studies have negative results. However, a Helicobacter pylori infection is often considered to be a potential cause of LG.

Lymphocytic Gastritis Symptoms

Chronic LG can cause various clinical symptoms such as hypoproteinemia. Other symptoms may include early satiety, epigastric pain, weight loss and fatigue. However, in some cases it may not cause any noticeable symptoms.

Lymphocytic Gastritis and Celiac Disease

This condition is characterized by the lymphocytic infiltration of surface as well as pit epithelium. An association between LG and Celiac Disease has been shown by various studies. Some case studies even state the latter to be the cause of LG.

Picture of Lymphocytic Gastritis Picture 1 – Lymphocytic Gastritis

Around fifty per cent of patients suffering from Celiac Disease and flat duodenal mucosa are diagnosed with LG. Sufferers of this type of Gastritis often exhibit significantly high IEL counts in their duodenal mucosa, with many of them having an abnormally small intestinal permeability. It shows that sometimes people with this disorder may have some gastric mucosa reactions to gluten ingestion.

Lymphocytic Gastritis Diagnosis

Severe forms of the condition are diagnosed in a manner similar to Varioliform gastritis. Diagnostic tests are likely to show at least twenty-five lymphocytes or hundred epithelial cells to confirm the presence of LG. Endoscopy is commonly used for diagnosing this disease.

Lymphocytic Gastritis Differential Diagnosis

Pathologists diagnosing the condition should distinguish LG from the B-cell lymphoepithelial lesions caused by MALT lymphomas. Monomorphic infiltration in lamina propria is another health issue to be considered during the differential diagnosis of this disease.

Image of Lymphocytic Gastritis

Picture 2 – Lymphocytic Gastritis Image

Lymphocytic Gastritis Treatment and Management

A gluten-free diet helps in the treatment of this disorder in patients suffering from Celiac Disease as well LG. LG patients histologically or serologically diagnosed with H. pylori infection can be treated with triple therapy. They should undergo histology and serology 6 to 18 months after the therapy to see if the condition is recurring. According to some studies, exudative LG can be treated successfully using omeprazole.

Lymphocytic Gastritis Prognosis

The prognosis or outcome of treatment of the disease depends on various factors and may vary from one person to another. In most cases, however, the outcome is positive with proper and timely treatment.   Lymphocytic Gastritis is generally a non-fatal condition. It is important to diagnose the condition at an early stage which may not be possible in cases where it does not cause any visible symptoms. Timely treatment helps to cure the disease. References:

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